Is sucralose safe? (an artifical sugar)


Take home message

Splenda is the most popular artificial sweetener. It is heat stable and can be used in baking.


The FDA reviewed more than 110 studies before, in 1998, approving it as an artificial sweetener.

The results of the studies showed no evidence that it can cause cancer or pose a threat to human health. 

Per FDA, the amount that a normal person can consume the equivalent of 23 Splenda packets every day for an entire lifetime, without an adverse health effect. 


Background



Sucralose Acesulfame Potassium
Sucralose yes No
Splenda yes No
Mt. Dew (also contains aspartame) yes Yes
Pepsi, Diet yes Yes

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Sources

American Heart Association's statement regarding artificial sweeteners

NIH: Cancer Research Institute's statement regarding artificial sweeteners   

Bradstock, MK and others. Evaluation of reactions to food additives: the aspartame experience. Journal of Clinical Nutrition, March 1986.

Blackburn, GL and others. The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight. Journal of Clinical Nutrition, February 1997.

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Dagfinn, Arne. Soft drinks, aspartame, and the risk of cancer and cardiovascular disease. Journal of Clinical Nutrition, December 2012.

Drewnowski, A and others. Comparing the effects of aspartame and sucrose on motivational ratings, taste preferences, and energy intakes in humans. Journal of Clinical Nutrition, February 1994.

Harvard University Artificial Sweeteners

Nutrition 101: Replacing Sugar by Nonnutritive Sweeteners, Nutrition 101 Macronutrients Lesson 3.3, Dr Sander Kirstein, Wageningen University, Netherlands.

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Schernhammer, Eva S. and others. Consumption of artificial sweetener– and sugar-containing soda and risk of lymphoma and leukemia in men and women. Journal of Clinical Nutrition, December 2012.

Spiera PA and other. Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects. Journal of Clinical Nutrition, September 1998.

Stegink, LD. The aspartame story: a model for the clinical testing of a food additive. July 1987.

Stegink, LD and others. Effect of sucrose on the metabolic disposition of aspartame. Journal of Clinical Nutrition, August 1990.

Stegink, LD and others. Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine and aspartate concentrations in children consuming diets high in aspartame. Journal of Clinical Nutrition, December 1995.

Turnoff MJ and AM Alleva.  Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight, Journal of Clinical Nutrition, June 1990

US Food and Drug Administration. Additional Information about High-Intensity Sweeteners Permitted for use in Food in the United States

_____ High Intensity Sweeteners